Meta-analysis of the effect of systemic metronidazole as an adjunct to scaling and root planing for adult periodontitis.

نویسندگان

  • J R Elter
  • H P Lawrence
  • S Offenbacher
  • J D Beck
چکیده

The purpose of this meta-analysis was to provide a quantitative overview of clinical trials assessing the use of systemic metronidazole (S-MET) as an adjunct to scaling and root planning (S&RP) in the treatment of adult periodontitis. Eight clinical trials were chosen based upon a priori selection criteria, and two outcomes, "reduction in probing pocket depth" (PD) and "gain in clinical attachment level" (CAL), were analyzed. Results for each outcome were stratified by initial PD 1-3 mm, 4-6 mm, or > or = 7 mm and length of follow-up 4-6 wk, 9-13 wk, or 14-26 wk. S-MET in conjunction with S&RP was superior to S&RP alone in reducing PD where initial PD was 4-6 mm and follow-up was 9-13 wk (0.43 mm; 99% CI 0.12, 0.73). No significant advantage was observed for S-MET for reducing PD where initial PD was less than 4 mm or follow-up was longer than 13 wk. S-MET in conjunction with S&RP was superior to S&RP alone in reducing CAL where initial PD was 4-6 mm and follow-up was 4-6 wk (0.29; 99% CI 0.01, 0.58) and where follow-up was 9-13 wk (weighted mean difference 0.32; 99% CI 0.03, 0.61). Significant heterogeneity of effect was not seen for PD or Cal at any level of initial PD or length of follow-up. No significant dose-response relationship was observed. This meta-analysis was limited due to diversity of data presentation and the small number of trials in each stratum. These results suggest that S-MET in conjunction with S&RP may offer a benefit over S&RP alone in the treatment of adult periodontitis patients in managing pockets of 4 mm or greater, but the additional benefit was not evident if initial PD was less than 4 mm or follow-up was beyond 13 wk.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی اثر آموکسی سیلین و مترونیدازول به عنوان یک درمان مکمل به منظور جرم گیری و تسطیح ریشه دندان ها در بیماران مبتلا به پریودنتیت مزمن

Introduction & Objective: Chronic periodontitis is an inflammatory disease of the tooth supporting tissues by a specific group of microorganisms, leading to progressive destruction of the periodontal ligament. The aim of this study was to evaluate the effect of amoxicillin and metronidazole as an adjunct, after scaling and root planning in reducing pocket depth and clinical attachment loss in...

متن کامل

The Effects of Diode Laser as an Adjunct to Scaling and Root Planing on Treatment of Chronic Periodontitis: A Review of the literature

Background and aim: The most common form of periodontitis is chronic periodontitis, which is a destructive inflammatory disease of periodontal tissues and is usually associated with pocket formation, changes in density and height of alveolar bone, and sometimes gingival recession. Some patients are resistant to periodontitis treatment due to a weak immune system, smoking, and sometimes due to u...

متن کامل

Adjunctive effects of systemic amoxicillin and metronidazole with scaling and root planing: a randomized, placebo controlled clinical trial.

AIMS The objective of this study was to investigate the effect of the systemic administration of metronidazole and amoxicillin as an adjunct to initial periodontal therapy in patients with moderate to severe chronic periodontitis. METHODS AND MATERIALS This randomized, double blind, placebo controlled parallel study involved 50 adult patients with untreated periodontitis who were randomly ass...

متن کامل

Antimicrobial or Subantimicrobial Antibiotic Therapy as an Adjunct to the Nonsurgical Periodontal Treatment: A Meta-Analysis

The use of antibiotics in nonsurgical periodontal treatment is indicated in cases in which scaling and root planing present important limitations. However, their use is controversial due to the secondary effects associated with them and the disagreements regarding their prescription. The aim of this study is to determine the effectiveness of systemic antibiotics in the management of aggressive ...

متن کامل

The concomitant administration of systemic amoxicillin and metronidazole compared to scaling and root planing alone in treating periodontitis: =a systematic review=

BACKGROUND The treatment of periodontitis begins with a non-surgical phase that includes scaling and root planing(SRP) and on occasion the use of systemic antibiotics. The goal was to systematically evaluate in systemic healthy adults the effect of the concomitant administration of amoxicillin (amx) and metronidazole (met) adjunctive to SRP compared to SRP alone. METHODS The PubMed-MEDLINE, C...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Journal of periodontal research

دوره 32 6  شماره 

صفحات  -

تاریخ انتشار 1997